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KMID : 1134819990280051107
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 5 p.1107 ~ p.1112
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Anticancer Activity of Phytol and Eicosatrienoic Acid Identified from Perilla Leaves
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Lee Kyeong-Im
Lee Sook-Hee
Park Kun-Young
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Abstract
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We investigated the inhibitory effects of phytol and methyl 11,14,17-eicosatrienoic acid (methyl ETA, n-3, 20 : 3) separated from perilla leaves on the growth of human cancer cells. Phytol inhibited significantly the growth of HT-29 human colon cancer cells, MG-63 osteosarcoma cells and AZ-521 gastric cancer cells. Although the activity of methyl ETA was lower than that of phytol, it was also observed to have the inhibitory effect on three human cancer cell lines. Furthermore, the DNA synthesis of the MG-63 osteosarcoma cells was markedly decreased by the addition of the phytol and methyl ETA. These results suggest that phytol and methyl ETA identified from the perilla leaves may playa role on the growth inhibition of the human cancer cells.
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KEYWORD
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phytol, methyl 11, 14, 17-eicosatrienoic acid, human cancer cells
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